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Travel Vaccines and Advice for Central and Southern Africa

Central and Southern Africa is one of the most popular destinations for travelers. Safaris in South Africa, hiking at Kilimanjaro and sunbathing at amazing beaches. There’s plenty to experience.

On This Page:
What Vaccines Do I Need for Central and Southern Africa?
Are There Other Health Concerns in Central and Southern Africa?
What Are the Entry Requirements in Central and Southern Africa?
Traveling to Another Destination?

Passport Health offers a variety of immunizations and medications to help you travel safely. Some are even required to enter countries. See our What Vaccines… section to learn more.

Countries in this region include:

Angola
Botswana
Burundi
Cameroon
Central African Republic
Chad
Comoros
Democratic Republic
of the Congo
Djibouti
Equatorial Guinea
Eswatini
Ethiopia
Eritrea
Gabon
Kenya
Lesotho
Madagascar
Malawi
Mauritius
Mayotte
Mozambique
Namibia
Republic of the Congo
Réunion
Rwanda
São Tomé and Príncipe
Seychelles
Somalia
South Africa
South Sudan
Tanzania
Uganda
Zambia
Zimbabwe

The CDC and WHO recommend the following vaccinations for travelers to Central and Southern Africa: hepatitis A, hepatitis B, typhoid, cholera, yellow fever, rabies, meningitis and polio.

A variety of routine vaccinations are also recommended: measles, mumps and rubella (MMR), tetanus, diphtheria and pertussis (Tdap), influenza, chickenpox, shingles, pneumonia.

COVID-19 vaccination is recommended for travel to all regions, both foreign and domestic. Check with your local Passport Health clinic if immunization is offered in your area.

Proof of yellow fever vaccination is required for most countries, especially if you are traveling to more than one. Make sure you can travel easily with Passport Health.

See the table below for more information:

Recommended Travel Vaccinations for Central and Southern America
VACCINE HOW DISEASE SPREADS DETAILS
COVID-19 Airborne & Direct Contact Recommended for all unvaccinated individuals who qualify for vaccination
Hepatitis A Contaminated Food
or Water 		Recommended for most
travelers to all regions.
Hepatitis B Contaminated Body
Fluids (Sex, needles, etc.) 		Recommended for most
travelers to all regions.
Typhoid Contaminated Food
or Water 		Recommended for most
travelers to all regions.
Cholera Contaminated Food
or Water 		May be recommended based
on your specific itinerary.
Yellow Fever Mosquito-borne May be recommended or required
for most of the region.
Rabies Infected Animals Vaccine recommended for long-term travelers
and those who may come in contact with animals.
Meningitis Airborne or
Direct Contact 		Normally, a routine vaccination.
Active transmission in some parts of the region.
Polio Contaminated Food
or Water 		Generally considered a routine vaccination.
Present in some countries in the region.

Recommended Routine Vaccinations for Central and Southern Africa
VACCINE HOW DISEASE SPREADS DETAILS
Measles Mumps Rubella (MMR) Various Vectors Given to anyone unvaccinated and/or born
after 1957. One time adult booster recommended.
Tdap (Tetanus, Diphtheria and Pertussis) Wounds or
Airborne 		One adult booster of pertussis recommended
for most travelers.
Influenza Airborne Generally recommended for all travelers.
Vaccine components change annually.
Chickenpox Direct Contact
or Airborne 		Given to those unvaccinated that
did not have chickenpox.
Shingles Direct Contact Recommended for individuals 50+. Vaccine can
still be given if you have had shingles.
Pneumonia Airborne All individuals 65+ or immunocompromised
should receive this vaccine.

Sources: CDC, WHO and ISTM

Customer Reviews

Passport Health – Travel Vaccines for Central and Southern Africa

Overall rating: 5 stars – 10 reviews
★★★★★
“Great service!“
“The nurse provided thorough information about the vaccinations that we needed or was recommended for our trip to Central Africa. She was friendly and engaging as she explained what was needed and offered products that we might use.”

Submitted by: Duane
★★★★★
“Best service“
“Wonderful service and great information about Southern Africa. I felt like I was in good hands. All my questions were answered and explained simply.”

Submitted by: Madison
★★★★★
“Thank you!“
“The staff are fabulous. They made my trip to Africa a stress-free adventure, and the B12 shot was a miracle for me. I’m immensely grateful for their assist in scoring a perfect family vacation!”

Submitted by: Erin
★★★★★
“Very very helpful“
“Our nurse was very nice and explained everything well to us. We feel ready for our trip to Africa.”

Submitted by: Laura
★★★★★
“Great travel clinic“
“It was great to get detailed printed information for the various destinations we’re going to in Africa. The nurse was very knowledgeable and helpful.”

Submitted by: Marilyn
★★★★★
“Excellent & Friendly Service“
“Great work to assist me with travel immunizations for Central Africa on very short notice. The staff was professional, friendly and respectful of my time. The office is clean, neat and very professional. I highly recommend this service and friendly staff.”

Submitted by: Ned
★★★★★
“Fast and no hassles“
“I was early had miles to go and she got me in fast. The additional information about Southern Africa will come in handy on our safari.”

Submitted by: Layne
★★★★★
“Fantastic help!“
“The nurse was fantastic! Incredibly knowledgeable about Central Africa, helpful, and kind. Thank you so much!”

Submitted by: Matthew
★★★★★
“Very thorough!“
“The nurse was awesome! Walked us through all of our options for Southern Africa in great detail and prepared us for our trip.”

Submitted by: Mike
★★★★★
“Great Staff“
“Went here for a ton of shots for an upcoming assignment in Africa. The Nursing staff is OUTSTANDING. I will go back and recommend.”

Submitted by: Thomas

A wide range of infections call Central and Southern Africa home.

Mosquito-borne Infections

Malaria is found in many of the countries in the region. Be sure to see your destination’s advice page and consult with a Passport Health travel health specialist.

Dengue, chikungunya and even Zika can be found in some parts of Central and Southern Africa. While there are no medications or vaccines to prevent these infection, there are things you can do. Be sure to use mosquito repellent regularly and consider using mosquito netting when outside. Avoid the outdoors at dawn and dusk, when mosquitoes are most active.

Other Infections

A few countries in the region have had Ebola outbreaks over the last decade. While outbreaks are rare, they are also possible. If you hear of an outbreak in an area you will be traveling to, be sure to contact a Passport Health travel health specialist.

Travelers’ diarrhea is the most common risk to travelers in Central and Southern Africa. Be sure to have a travelers’ diarrhea kit as part of your preparations. These include items that can help prevent the illness or stop symptoms as quickly as they start.

Visas are required for the majority of countries in Central and Southern Africa. Often proof of yellow fever vaccination is also a requirement. Make sure you have both before leaving for your trip.

See the below table for more information:

Do I Need a Passport or Visa for My Trip?
Passport Tourist Visa Business Visa Required
Vaccinations
Angola table check mark table check mark table check mark table check mark
Botswana table check mark table check mark
Burundi table check mark table check mark table check mark table check mark
Cameroon table check mark table check mark table check mark table check mark
Central African Republic table check mark table check mark table check mark table check mark
Chad table check mark table check mark table check mark table check mark
Comoros table check mark table check mark table check mark
Democratic Republic
of the Congo		 table check mark table check mark table check mark table check mark
Djibouti table check mark table check mark table check mark table check mark
Equatorial
Guinea		 table check mark table check mark
Eritrea table check mark table check mark table check mark table check mark
Eswatini table check mark table check mark
Ethiopia table check mark table check mark table check mark table check mark
Gabon table check mark table check mark table check mark table check mark
Kenya table check mark table check mark table check mark table check mark
Lesotho table check mark table check mark
Madagascar table check mark table check mark table check mark table check mark
Malawi table check mark table check mark table check mark table check mark
Mauritius table check mark table check mark
Mayotte table check mark table check mark
Mozambique table check mark table check mark table check mark table check mark
Namibia table check mark table check mark table check mark table check mark
Republic of the Congo table check mark table check mark table check mark table check mark
Réunion table check mark table check mark
São Tomé and Príncipe table check mark table check mark
Somalia table check mark table check mark table check mark table check mark
South Africa table check mark table check mark
South Sudan table check mark table check mark table check mark table check mark
Tanzania table check mark table check mark table check mark table check mark
Uganda table check mark table check mark table check mark table check mark
Zambia table check mark table check mark table check mark table check mark
Zimbabwe table check mark table check mark table check mark table check mark

Embassy information for each country is available on its own destination advice page.

Traveling outside of Central and Southern America? Learn more about your destination with our full compliment of destination advice pages!

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