From the first cholera vaccine created in 1885 to one approved by the FDA in 2016, the world has a much better understanding of the disease and its epidemics. That’s why knowing how vaccination prevention works is such an important tool.

Cholera is a bacterial disease the can be transmitted in water or food contaminated with Vibrio cholerae bacteria.

Symptoms from the disease can range from mild to fatal. Cholera typically causes symptoms like diarrhea and vomiting. Both of which can lead to death due to dehydration if left untreated.

Origins of the disease trace back to approximately 500 B.C. Since then, there have been two “first” genuine discoveries of cholera’s bacteria, once in the 1850s and once in the 1880s.

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Jet lag is one of the most frequent complaints of travelers.

People anxiously await the holiday in another country, and upon their arrival, feel exhausted. The plans that they made previously made sometimes have to change, at least temporarily.

Jet lag happens when people travel east to west, or vice versa, and span a few time zones. This shift in time throws their system off and out of sync. Some symptoms of jet lag are headaches, insomnia, irritability and imbalance problems because of the changes in the inner ear. So, how does a person beat these symptoms so they can enjoy their vacation?

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Scientists in British Columbia, Canada, have found the path of a 2010 measles outbreak linked to the Vancouver Olympics, but their research has also given us a look into the importance of vaccination.

The research, which was published in the Journal of Infectious Diseases, followed the spread of the measles virus almost immediately after the 2010 Olympics. Through genome sequencing, the researchers were able to track the virus’s spread and identify where it likely originated from.

Of the two strains, one spread throughout a general area while the other took a slightly different route and could be seen following a single highway, slowly spreading north.

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Heroes are cool, but it’s really easy to rally around a good villain.

The Lex Luthors. The Hans Grubers. The Lord Voldemorts.

It’s much harder to pinpoint the bad guy when it comes to disease.

While germs and bacteria make up the illness, they don’t provide a visible target to resent.

No, the blame and contempt for an epidemic often falls on “patient zero”.

This is how we get legends like Typhoid Mary. Vilified for carrying the deadly disease throughout New York, even though she had no idea what her actions could create.

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Imagine a plague that infected millions in just a year, killing as many as 5,000 people per day. For the Eastern Roman (Byzantine) Empire, this nightmare was a reality. Beginning in about 541 CE, the Plague of Justinian swept through Europe, killing up to a quarter of the Eastern Mediterranean population and possibly as much as 10 percent of the world’s population.

What Was The Plague of Justinian?

Despite the catchy name, the Plague of Justinian was identified as the bubonic plague, otherwise known for its 14th Century cousin, “The Black Death.” The disease earned its name from Justinian, the ruler of the Byzantine Empire at the time. It also has a double meaning, as Justinian’s handling of the crisis was almost its own form of infection.

As farmers and other workers were dying by the thousands, Justinian was unable to complete many of the projects he had started and began to raise taxes and change the tax code.

Procopius, a scholar of the time, explained:

“When pestilence swept through the whole known world and notably the Roman Empire, wiping out most of the farming community and of necessity leaving a trail of desolation in its wake, Justinian showed no mercy towards the ruined freeholders. Even then, he did not refrain from demanding the annual tax, not only the amount at which he assessed each individual, but also the amount for which his deceased neighbors were liable.”

What Were the Symptoms of the Plague?

We don’t know the exact symptoms of the Plague of Justinian. The current symptoms for bubonic plague include:

• Fever
• Headache
• Chills
• Swollen or tender lymph nodes
• Abdominal pain
• Gangrene

Procopius described victims suffering from these and also other symptoms including:

• Delusions
• Nightmares
• Comas

He even said some would die almost immediately after the onset of symptoms. However, we don’t know how accurate his reporting was. Procopius said the plague was killing 10,000 people every day, but modern estimates put the daily death toll to closer to 5,000.

How and Where Did the Plague Spread?

Like the modern bubonic plague, scientists believe the Plague of Justinian spread through fleas. Studies indicate the plague may have originated in China or India and was then transported to the fertile valleys of Egypt through trade routes. In 541, the Egyptian port of Pelusium was the first city to document cases, and, by 542, cases were seen as far north as England.

Due to the nature of ancient records, we don’t know the full extent of the disease’s spread. We know the Mediterranean region was the hardest hit, but anecdotal evidence indicates some cases occurred in England, Germany and other northern regions.

What Effects Did the Plague Have?

Justinian wasn’t just a leader; he was also a conqueror. By 542, he had reconquered most of the Roman Empire’s previous domain and was hoping to solidify his rule. The plague made this all but impossible as farmers, soldiers and other key members of society fell ill and died from the disease.

By 568, Justinian’s empire began to crumble as the Lombards invaded Northern Italy, and, within a few generations, enemies were at the gates. Byzantium remained a power through 1453, but it would never be as large as it had been before the plague.

Could The Plague of Justinian Resurface?

Just as with many other ancient diseases, this question has been under investigation for years. A study conducted by Northern Arizona University found the Plague of Justinian came from a now extinct form of Y. pestis or bubonic plague. So in short, it is still around. But, we are unlikely to see anything like Justinian’s Plague or the Black Death in modern times.

“We’ve greatly improved hygiene since the times of the great pandemics,” said one researcher. “The other thing is we not have antibiotics, and plague is susceptible to every antibiotic.”

To learn more about bubonic plague, see the CDC portal. To learn more about other eradicated, or nearly eradicated diseases, see our polio and measles, mumps and rubella pages.

If you are planning a trip, especially one where you may come in contact with rodents, book an appointment at your local Passport Health by calling or booking online today.

What are your thoughts on this terrible plague? Let us know in the comments below, on Facebook or Twitter.