A new study in Science identified piperacillin for treating Lyme disease. Researchers tested nearly 500 FDA-approved compounds to find effective drugs. Piperacillin, related to penicillin, best eliminated Lyme-causing bacteria, Borrelia burgdorferi.
Doxycycline is currently the main treatment but has significant drawbacks. It harms helpful gut bacteria, causes side effects, and affects children negatively. Doxycycline also leaves 10–20% of Lyme disease cases incompletely treated. Piperacillin provides targeted treatment of Borrelia burgdorferi with fewer side effects.